![]() ![]() Furthermore, apart from being a highly debilitating disease, Alzheimer's disease is associated to elevated cost of care valued at more than $232 billion and causes great emotional distress to family members. Nowadays, Alzheimer's disease affects over 30 million individuals and this number is expected to increase to 114 million by 2050. Alzheimer's disease was later defined as a severe age-related neurodegenerative condition, characterized by a progressive decline in language ability, memory loss, and cognitive impairment accompanied by deterioration of brain tissue, subsequently leading to death. About 70 years have passed before this outstanding contribution to the history of medical science was recognized by the medical community and became a significant focus for research. Alois Alzheimer in 1906 following his observations of the morphological and histological changes of the brain of a 51-year-old lady who deceased after 4 years of suffering. Known to be the most common form of dementia, Alzheimer's disease was discovered by Dr. ![]() Age-related neurodegenerative diseases are of critical concern to the general population and research/medical community due to their health impact and socioeconomic consequences. With the aging of the global population, the prevalence of neurodegenerative disorders has markedly increased. Indeed, with substantial advances in the medical field, life expectancy has increased and the global elderly population continues to crop up at an unprecedented rate. Neurodegenerative diseases are often classified as diseases of the old aged people. Neurodegenerative diseases are marked by progressive dysfunction and loss of neurons within the brain and/or the spinal cord, affecting cognition, memory, coordination, gait, and motion. ![]() The famous quote of Leonardo da Vinci's, “ whose soul cannot control their movements in spite of the fact that their extremities are shaking continuously” suggests that neurodegenerative conditions have been occurring long ago. Mahomoodally, in Studies in Natural Products Chemistry, 2019 Neurodegenerative diseases ![]()
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